$700 million mark was passed in the philanthropic giving of brothers 36-year-old Patrick and 35-year-old John Collison

Patrick and John Collison, the Irish-born brothers who co-founded Stripe, are marking 2025 with a series of major philanthropic moves that are redefining their public footprint.

Already known for committing more than $650 million to the Arc Institute—a biomedical research nonprofit they co-founded in Palo Alto to accelerate breakthroughs in disease prevention and treatment—the siblings are now directing fresh resources toward science education, technology policy, and public health.

That Arc commitment, one of the most significant single sums linked to the brothers, remains the backbone of their giving, supported by additional multimillion-dollar infusions each year to sustain and expand the institute’s research capacity.

In Ireland, their philanthropy has taken on a personal dimension. A five-year health initiative launched in 2024, funded in the millions by the Collisons, aims to halve the time it takes to diagnose cerebral palsy in newborns.

Early data from the program’s first year indicate faster access to life-altering therapies for infants nationwide.

This follows other Ireland-based commitments, including several million euros in community health and development grants.

Their science and education focus also deepened in May 2025 when Stripe stepped in as the new five-year title sponsor of the Young Scientist and Technology Exhibition, replacing BT Ireland.

While the sponsorship sum has not been publicly disclosed, insiders describe it as “significant,” with Stripe funding upgrades to exhibition infrastructure and expanded outreach to rural schools.

Patrick, who won the exhibition in 2005, called the move a way of “paying forward” the opportunities it gave him and his brother.

Beyond direct grants, the Collisons’ COVID-era Fast Grants program—an effort that distributed more than $50 million to scientists within days of application—remains a touchstone for their philosophy of cutting through bureaucracy to accelerate impact.

More recent donations include $1 million to California YIMBY and continued financial backing for the “California Forever” urban planning initiative.

While their total personal giving is difficult to calculate precisely, available public records and self-reported figures indicate that it is well above $700 million, with the vast majority concentrated in long-term science, health, and technology projects.

Even as they step into high-profile roles—Patrick joined Meta’s board in 2025—the brothers maintain an unusually hands-on approach to their philanthropy, often visiting labs, policy roundtables, and community events connected to their causes.

For the Collisons, giving is not simply a ledger of large numbers; it is a sustained, personal engagement with the ideas and institutions they believe can change the world.